Antibacterial Activities of New Compounds Nitrogen Heterocyclic Saturated

Leila Lefrada

Abstract


This work describes the synthesis, spectroscopic, structural characterization and antibacterial activities of new saturated heterocyclic nitrogen compounds of the 1, 3, 5-triazacyclohexane type.

     The new triazacyclohexanes (R3TAC) with mixed aryl and alkyl N-substituents are synthesized by the reaction of a 1:1 mixture of 4-iodoaniline and 2-ethyl1-hexyl amine with formalin. The synthesized compounds were characterized by spectral analysis IR, 1H NMR and 13C NMR and shown to be mainly a mixture of the two mixed triazacylcohexane.

    These compounds were screened for their antibacterial activity against Gram-positive and Gram-negative bacteria by the diffusion method on agar medium. 


Keywords


synthesis; triazacyclohexanes; antibacteria

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References


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in the 23S rRNA Gene and

Loss of a Single Copy of rRNA, J. Infect. Dis. DrugTargets, 190 (2004) 311-317

M. Chebbah, A. Messai, D. Bilge, A. Bouchemma, C. Parlak. New unsymmetrically substituted triazacyclohexanes. Synthesis,characterisation, antimicrobial properties and DFT study, Journal of Molecular Structure 1129 (2017) 152-159.

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DOI: http://dx.doi.org/10.5281/zenodo.889066

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