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Published September 11, 2017 | Version v1
Journal article Open

Antibacterial Activities of New Saturated Heterocyclic Nitrogen Compounds

  • 1. Faculty of Exact Sciences, Department of Material Science, University Larbi Ben M'hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria
  • 2. Departement of Chemistry University of Bath, Bath, BA2 7AY, UK
  • 3. Département de Biologie, Faculté des Sciences, Université Badji Mokhtar, 2300 Annaba, Algérie.

Description

This work describes the synthesis, spectroscopic, structural characterization and antibacterial activities of new saturated heterocyclic nitrogen compounds of the 1, 3, 5-triazacyclohexane type.

     The new triazacyclohexanes (R3TAC) with mixed aryl and alkyl N-substituents are synthesized by the reaction of a 1:1 mixture of 4-iodoaniline and 2-ethyl1-hexyl amine with formalin. The synthesized compounds were characterized by spectral analysis IR, 1H NMR and 13C NMR and shown to be mainly a mixture of the two mixed triazacylcohexane.

    These compounds were screened for their antibacterial activity against Gram-positive and Gram-negative bacteria by the diffusion method on agar medium.

 

 

 

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