ANTIDIABETIC ACTIVITY OF MORINGA OLEIFERA LAM.

Ameebahen B PATEL, Dr. Dharmeshkumar Dhulabhai Prajapati, YOGESHKUMAR PATEL

Abstract


Diabetes mellitus is a clinical syndrome with insufficient insulin secretion, abnormal glucose tolerance, universal, microangiopathia, neuropathia, accentuated atherosclerotic changes. Moringa oleifera Lam (Moringaceae) leaves are emetic and their juice with black pepper is used in headache. The leaves are anthelmintic, aphrodisiac, cures hallucinations, antidiabetic, dry tumors, cough and asthma. Different extracts of Moringa oleifera prepared in different solvents and used in alloxan induced diabetic rats. Total alcohol, Successive alcohol and Successive chloroform significantly decreases the serum cholesterol, serum triglyceride, serum VLDL, serum LDL and  Total alcohol extract increases the serum HDL level in alloxan induced diabetic rats. The plant is worth for antidiabetic activity. So this result provides a platform for the drug designers and gives them an opportunity to prepare such herbal formulations which can be used as to treatment on diabetes.


Keywords


Moringa oleifera, Antidiabetic, Diabetes mellitus

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References


Hakim, Z. S. Potential Antidiabetic Agents from Plant Sources: Pharmacological Aspects. Indian J Natural Product 11(1); (1995) 3.

Pickup, J. C. Text Book of Diabetes, Black Well Scientific Publication, 2 nd edn.; 1991; 37-44.

Tiwari, A. K.; Rao, J. M. Diabetes Mellitus and multiple therapeutic approaches of phytochemicals: present status and future prospectus. Current Science 83(1);(2002) 30-38.

Gupta, A.K.; Tandan, N.; Sharma, N.; Quality Standards of Indian Medicinal Plants, ICMR , 2005; Volume 3, pp 272-278.

Goyal, B. R.; Agrawal, B. B.; Goyal, R. K.; Mehta, A. A.; Phyto pharmacology of Moringa oleifera Lam.-An Overview, Natural Product Radiance. 6(4); (2007) 347-353.

Kannur, D. M.; Hukkeri, V.I.; Akki, K.S.; Anti-diabetic activity of Caesalpinia bonduucella seed extracts in rats. Fitoterapia.( 2006) 77:546-49.

Cromwell, B.T; Peach, K; Tracey, M.V. Modern Methods of Plant Analysis. In: alkaloids. SpringerVerlag, Berlin, 1955; Volume 3 (1) 373-374

Kokate, C.K; Purohit, A.P; Gokhale, S.B. 30thedition, Pharmacognosy In: alkaloid. Pune, Nirali Prakashan, 1996, 447.

Geinssman, T.A; Peach, K.; Tracey, M.V. Modern Methods of Plant Analysis Springer Verlag, Berlin. 1955, Vol. 3, 500-504.

Hawks, P. B.; Physiological chemistry. In: Carbohydrates. New Delhi. Tata McGraw Hill Publishing Company Ltd. 1971, 373.

Chatterjee, T.K.; Hand book on Laboratory Mice and Rats. 1sted. Mitra R N publishers, Calcutta, 1993, 53-61.

Ghosh, M.N.; Fundamentals of Experimental Pharmacology; Scientific book Agency, Calcutta, 1998, 76.

Vogel, G.H,; Wolf, G.; Vogel, H.; Drug discovery and Evaluation Pharmacological Assay. IInd ed. Springer-Verlag, Heidel berg, (NY); 2002.




DOI: http://dx.doi.org/10.5281/zenodo.865484

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