Antiacetylcholinesterase Activitie of Sweet Orange (Citrus Sinensis) Essential Oil from Algeria.

Hicham Boughendjioua


Natural products have been the source of new drugs since ancient times. Plants are a good source of secondary metabolites which have been found to have beneficial properties. The purpose of this research was to evaluate the chemical composition by gas chromatography coupled with mass spectrometry (GCMS) and acetylcholinesterase inhibitory activity was also determined of sweet orange (Citrus sinensis) essential oil.

The main components of the essential oil were Limonene (89.547 %), β.-Myrcene (4.106 %), β.-Phellandrene (1.670 %), α.-Pinene (1.312 %).

The results of these studies clearly demonstrate that orange may represent a valuable source of new secondary metabolites with high diverse biological activities, in particular for finding new natural Acetylcholinesterase AChE inhibitors, with an (IC50 = 35.07 ± 2.47 μg. mL-1) for the essential oil compared to (IC50 = 6.27 ± 1.15 μg. mL-1) for Galantamine.


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