Synthesis and Antimicrobial activities of Aziridines-tosylates Derivative

Assia Keniche

Abstract


By using simple straightforward synthesis of Tosylate aziridines has been developed. By means of this synthetic strategy from readily available N-phtaloyl acide and 2-methylbenzosulfonate aziridine using DCC as coupling agent, new tosylates aziridines could be obtained. The coupling reactions occurred without ring opening of the three membered ring. This work describes new results of our ongoing research targeting new derivatives of biological interest. All the compounds were screened for their antibacterial activity, they all showed comparable moderate to good growth inhibitory activity with reference to Tetracyclin and Gentamicin.


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DOI: http://dx.doi.org/10.5281/zenodo.4282237

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