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Email this article Afzelia africana Seed Extract: Toxicity, Antidiarrhoeal and Chemical Assays
Abstract
Diarrhoea is the second cause of death associated with children below five years. This study investigated the chemical profile, toxicity and antidiarrhoeal property of ethanol extract of Afzelia africana seed. Chemical profiling was established via GC-MS. Acute toxicity was evaluated using standard protocol and antidiarrhoeal assay was carried out on graded doses (25, 50, and 100 mg/kg) of extract. GC-MS revealed the presence of 2,5-octadecadienoic acid (27.41%), oleic acid (6.34%) and phytol (6.23%) amongst others. Absence of mortality with no adverse effect was recorded at ? 5000 mg/kg. The castor oil induced diarrhoea model showed that the extract significantly delayed onset of diarrhoea, decreased frequency of defecation and weight of stool (p < 0.05). Similarly, a significant decrease in the length travel by charcoal meal was observed across the treated groups (p < 0.05). Thus, this study validated the folklore benefits of A. africana seeds as a potent antidiarrhoeal agent.
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