New aliphatic constituents from the aerial parts of Artemisia annua L.

Mohammed Ali

Abstract


Artemisia annua L. (Asteraceae) is an aromatic annual herb, up to 2 m in height, found in temperate Asia, especially China and naturalized in many countries of the world.  The plant is prescribed against fever, malaria, skin diseases, jaundice, malignant ulcers and haemorrhoids. Phytochemical investigation of the aerial parts of A. annua led to the isolation of alkyl alcohols, fatty acid esters, alkyl glucoside and fatty acids characterized as n-nonadecan-2β-ol (isononadecanol, 1), n-docosan-9β-ol (isodocosanol,  2), 1-octacosanol (n-octacosanyl alcohol, 3), n-heptadecanyl n-octadec-9,12-dienoate (n-heptadecanyl linoleate,  4), n-octadecanyl n-octadec-9,12,-dienoate (n-octadecanyl linoleate, 5), n-nonacosanyl n-octadec-9, 12-dienoate (n-nonacosanyl linoleate, 6), n-cos-(Z)-10-enoic acid (cis-cos-10-enoic acid, 7), n-cos-(Z)-9-enoic acid (cis-cos-9-enoic acid, 8) and n-heptadecanyl-ß-D-glucopyronoside (n-heptadecanyl glucoside, 9). The structures of all phytoconstituents, isolated for the first time from A. annua have been elucidated on the basis of spectral data analysis and chemical reactions

Keywords


Artemisia annua L., aerial parts, aliphatic phytoconstituents, structures elucidation

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References


Klayman, D.L.; Lin, A.J.; Acton, N. Isolation of artemisinin (qinghaosu) from Artemisia annua growing in the United States J Nat Prod., 47(4)) (1984) 715-717.

Mueller, M.S.; Karhagomba, I.B.; Hirt, H.M.; Wemakor, E. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. J Ethnopharmacol 73(3) (2000) 487-493.

Abdin, M.Z.; Israr, M.; Rehmann, R.U.; Jain, S.K. Artemisinin, a novel antimalarial drug. Biochemical and molecular approaches for enhanced production. Planta Med 69 (2003) 289-299.

Zheng, G.C. Cytotoxic terpenoids and flavonoids from Artemisia annua. Planta Med 60 (1) (1994) 54-57.

Mohamed, A.E.H.; El-Sayed, M.A.; Hegazy, M.E.; Helaly, S.E.; Esmail, A.M.; Mohamed, N.S. Chemical constituents and biological activities of Artemisia herba- alba. Rec Nat Prod 4 (2010) 1–25.

Ferreira, J.F.S.; Luthria, D.L.; Sasaki, T.; Heyerick, A. Flavonoids from Artemisia annua L. as antioxidants and their potential synergism with artemisinin against malaria and cancer. Molecules 15 (5) (2010) 3135–3170.

Lai, J.-P.; Lim, Y.H.; Su, J.; Shen, H.-M.; Ong, C.N. Identification and characterization of major flavonoids and caffeoylquinic acids in three Compositae plants by LC/DAD-APCI/MS J Chrom B 2007, 848, 215–225.

Brown, G.D. Two new compounds from Artemisia annua. J Nat Prod 55 (1992)1756–1760.

Bhakuni, R.S.; Jain, D.C.; Sharma, R.P.; Kumar, S. Secondary metabolites of Artemisia annua and their biological activity. Curr Sci 80 (2001) 35-48.

Elford, B.C.; Roberts, M.F.; Phillipson, J.D.; Wilson, R.J. Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones. Trans R Soc Trop Med Hyg 81 (1987) 434–436.

Rice-Evans, C.A.; Miller, N.J.; Paganga, G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Rad Biol Med 20 (1996) 933– 956.

Zhao, Y.W.; Ni, F.Y.; Song, Y.L.; Wang, S.Y.; Huang, W.Z.; Wang, Z.Z.; Xiao, W. Chemical constituents from Artemisia annua. Zhongguo Zhong Yao Za Zhi 39 (24) (2014) 4816-4821.

Anonymous. The Wealth of India, a dictionary of Indian raw materials and industrial products, National Institute of Science Communication and Information Resources, CSIR, New Delhi, First supplement, 1 (2006) 91-92.

Carbonara, T.; Pascale, R.; Argentieri , M.P.; Papadia, P.; Fanizzi, F.P.; Villanova, L.; Avato , P. Phytochemical analysis of a herbal tea from Artemisia annua L. J Pharma Biomed Analysis 62 (2012) 79–86.

Cavar, S.; Maksimovic, M.; Vidic, D.; Paric A. Chemical composition and antioxidant and antimicrobial activity of essential oil of Artemisia annua L. from Bosnia. Industrial Crops and Products. 37 (1) (2012) 479 – 485.

Bilia, A.R.; Santomauro, F.; Sacco, C.; Bergonzi, M.C.; Donato, R. Essential oil of Artemisia annua L.: an extraordinary component with numerous antimicrobial properties. Evidence-based Complementary and Alternative Medicine. 2014, Article ID 159819, 7 pages.

Goel, D.; Goel, R.; Singh, V.; Ali M.; Mallavarapu, G.R.; Kumar, S. Composition of the essential oil from the roots of Artemisia annua. J Nat Med 61 ((2007) 458-461.

Goel, D.; Singh, V.; Ali, M.; Mallavarapu, G.R.; Kumar, S. Essential oils of petal, leaf and stem of the antimalarial plant Artemisia annua. J Nat Med 61 (2007) 187-191.




DOI: http://dx.doi.org/10.5281/zenodo.1117151

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