Please use this identifier to cite or link to this item: http://univ-bejaia.dz/dspace/123456789/21075
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dc.contributor.authorFATMI, Sofiane-
dc.contributor.authorTAOUZINET, Lamia-
dc.contributor.authorTOUTOU, Zahra-
dc.contributor.authorCHIBANI, Nacera-
dc.contributor.authorSKIBA, Mohamed-
dc.contributor.authorIGUER-OUADA, Mokrane-
dc.date.accessioned2023-02-07T13:56:01Z-
dc.date.available2023-02-07T13:56:01Z-
dc.date.issued2022-01-27-
dc.identifier.issn2800-1729-
dc.identifier.urihttp://univ-bejaia.dz/dspace/123456789/21075-
dc.description.abstractCamptothecin is a promising anti-colorectal cancer agent. However, its use in clinical medicine is compromised by its low solubility and high instability in physiological media. The present work aims to study the chemical stability of the camptothecin lactone ring (alone, encapsulated, and in solid dispersion) while comparing it to that of a reference analog irinotecan. This stability is studied in acidic (pH 2) and physiological (saline) media and Human plasma by high performance liquid chromatography (HPLC). Stability tests carried out on CPT alone, encapsulated and in solid dispersion in artificial media and Human plasma demonstrate that ternary systems [CPT/β-CDs/PEG 6000 and CPT/PM-βCDs/PEG 6000] can lead to the protection of CPT lactone ring in physiological media and Human plasma for 72 hours. This protection is essential to the camptothecin therapeutic effect when administered in pharmaceutical form.en_US
dc.subjectCamptothecinen_US
dc.subjectChemical Stabilityen_US
dc.subjectColorectal Canceren_US
dc.subjectCyclodextrinen_US
dc.subjectIrinotecanen_US
dc.subjectPolyethylene Glycolen_US
dc.subjectSolid Dispersionen_US
dc.titleStability ring lactone study of camptothecin and irinotecan in artificial media and Human plasmaen_US
dc.typeArticleen_US
Appears in Collections:Biopolymer Applications Journal (BAJ)



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