| Titre : | Cancer bronchique primitif : étude rétrospective réalisée au sein du service de pneumophtisiologie du CHU de Bejaia sur l’année 2023 et le suivi des cas aux sein des services d’oncologie du CHU de Bejaia et de l’EPH d’Amizour | | Type de document : | document électronique | | Auteurs : | Hamouche, Maada, Auteur ; Kerrouche, Ounissa, Auteur ; Benchallal, Rahima, Directeur de thèse | | Editeur : | Bejaia : Université de Béjaia.Faculté de médecine | | Année de publication : | 2024 | | Importance : | 1 vol. (171 p.) | | Présentation : | (ill., fig.) | | Format : | CD-Room | | Note générale : | Bibliogr. | | Langues : | Français Langues originales : Français | | Mots-clés : | Cancer bronchique primitif Radio-chimiothérapie Tabac | | Index. décimale : | 616.994 Cancer | | Résumé : | Lung cancer represents one of the most pressing forms of cancer worldwide, primarily affecting the lungs and often developing insidiously without obvious symptoms in its early stages. Early diagnosis is crucial for improving outcomes. As research progresses and risk factors become better understood, there is growing hope for effective prevention strategies and treatments against this devastating disease. This study aimed to evaluate the epidemiological, radiological, clinical, histological profiles, diagnostic staging, and therapeutic management of patients with primary bronchial cancer within the Pneumology Department of CHU France Fanon, as well as their outcomes in the oncology departments of CHU Khlil Amrane and EPH Amizour.
This descriptive retrospective study examined 32 cases of primary bronchial cancer collected from the Pneumology Department of Bejaia in 2023. The mean age at diagnosis was 62.5 years, with a range of 39 to 86 years; nearly half of the diagnosed cases were in the 61 to 70 age group. A clear male predominance was observed, accounting for 78.78% of cases, with a male-to female ratio of 4:1. Smoking was present in 75% of cases, with an average consumption of 55 pack-years. The most common symptoms leading to consultation were dyspnea (48.57%), cough (37.14%), and chest pain (28.57%).
At diagnosis, 75% of patients exhibited general signs, while 46.87% had normal pleuropulmonary examinations. The most common radiological finding was rounded intra parenchymal opacity (59.37%), followed by hiliar opacities (25%) and atelectasis (12.5%).Bronchoscopic examination was performed in 81.25% of cases, with endobronchial protrusion observed in 30.26%. The positive diagnosis was primarily established through bronchofibroscopy in two-thirds of cases, followed by transthoracic biopsy in 12.5%. Adenocarcinomas were the most common histological type (53.12%), followed by squamous
cell carcinomas (25%) and small cell cancers (9.37%).
The diagnostic delay was between 5 and 15 days in nearly half of the cases (41.67%). Stage IV was the most prevalent, found in 62.5% of cases, followed by stage III (18.30%) and stage II(6.25%). The most frequently observed metastatic sites included liver (25.71%), brain (20%), and bone (17.14%).
In our sample, 63.15% received follow-up in the oncology department of CHU Khlil Amrane, and 26.31% in the oncology department of EPH Amizour. Regarding therapeutic options, 39.28% of patients were directed toward chemotherapy, while 7.18% were recommended for curative surgical intervention. After three cycles of chemotherapy, half of the patients showed disease progression, while one-third experienced stabilization.
After six cycles, six patients remained under treatment, with chemotherapy intensified for five cases, while one patient continued maintenance therapy. The majority of patients receiving radiotherapy underwent targeted radiotherapy, while others received palliative radiotherapy for bone and brain metastases.
This study highlights the urgent need for enhanced awareness and early detection strategies for primary bronchial cancer, emphasizing the importance of understanding epidemiological trends and therapeutic responses to improve patient outcomes. | | Note de contenu : | Mémoire de fin de cycle en vue de l'obtention du diplôme de docteur en sciences médicales |
Cancer bronchique primitif : étude rétrospective réalisée au sein du service de pneumophtisiologie du CHU de Bejaia sur l’année 2023 et le suivi des cas aux sein des services d’oncologie du CHU de Bejaia et de l’EPH d’Amizour [document électronique] / Hamouche, Maada, Auteur ; Kerrouche, Ounissa, Auteur ; Benchallal, Rahima, Directeur de thèse . - Bejaia : Université de Béjaia.Faculté de médecine, 2024 . - 1 vol. (171 p.) : (ill., fig.) ; CD-Room. Bibliogr. Langues : Français Langues originales : Français | Mots-clés : | Cancer bronchique primitif Radio-chimiothérapie Tabac | | Index. décimale : | 616.994 Cancer | | Résumé : | Lung cancer represents one of the most pressing forms of cancer worldwide, primarily affecting the lungs and often developing insidiously without obvious symptoms in its early stages. Early diagnosis is crucial for improving outcomes. As research progresses and risk factors become better understood, there is growing hope for effective prevention strategies and treatments against this devastating disease. This study aimed to evaluate the epidemiological, radiological, clinical, histological profiles, diagnostic staging, and therapeutic management of patients with primary bronchial cancer within the Pneumology Department of CHU France Fanon, as well as their outcomes in the oncology departments of CHU Khlil Amrane and EPH Amizour.
This descriptive retrospective study examined 32 cases of primary bronchial cancer collected from the Pneumology Department of Bejaia in 2023. The mean age at diagnosis was 62.5 years, with a range of 39 to 86 years; nearly half of the diagnosed cases were in the 61 to 70 age group. A clear male predominance was observed, accounting for 78.78% of cases, with a male-to female ratio of 4:1. Smoking was present in 75% of cases, with an average consumption of 55 pack-years. The most common symptoms leading to consultation were dyspnea (48.57%), cough (37.14%), and chest pain (28.57%).
At diagnosis, 75% of patients exhibited general signs, while 46.87% had normal pleuropulmonary examinations. The most common radiological finding was rounded intra parenchymal opacity (59.37%), followed by hiliar opacities (25%) and atelectasis (12.5%).Bronchoscopic examination was performed in 81.25% of cases, with endobronchial protrusion observed in 30.26%. The positive diagnosis was primarily established through bronchofibroscopy in two-thirds of cases, followed by transthoracic biopsy in 12.5%. Adenocarcinomas were the most common histological type (53.12%), followed by squamous
cell carcinomas (25%) and small cell cancers (9.37%).
The diagnostic delay was between 5 and 15 days in nearly half of the cases (41.67%). Stage IV was the most prevalent, found in 62.5% of cases, followed by stage III (18.30%) and stage II(6.25%). The most frequently observed metastatic sites included liver (25.71%), brain (20%), and bone (17.14%).
In our sample, 63.15% received follow-up in the oncology department of CHU Khlil Amrane, and 26.31% in the oncology department of EPH Amizour. Regarding therapeutic options, 39.28% of patients were directed toward chemotherapy, while 7.18% were recommended for curative surgical intervention. After three cycles of chemotherapy, half of the patients showed disease progression, while one-third experienced stabilization.
After six cycles, six patients remained under treatment, with chemotherapy intensified for five cases, while one patient continued maintenance therapy. The majority of patients receiving radiotherapy underwent targeted radiotherapy, while others received palliative radiotherapy for bone and brain metastases.
This study highlights the urgent need for enhanced awareness and early detection strategies for primary bronchial cancer, emphasizing the importance of understanding epidemiological trends and therapeutic responses to improve patient outcomes. | | Note de contenu : | Mémoire de fin de cycle en vue de l'obtention du diplôme de docteur en sciences médicales |
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Cancer bronchique primitif
