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The action of B2agonists formoterol and salbutamol on non -alcoholic fatty liver disease induced by a high -fat diet (HFD)biochemical approaches .

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dc.contributor.author Debbou, Melissa
dc.contributor.author Debbou, Yassina
dc.contributor.author Amirouche, Adel (enc)
dc.date.accessioned 2024-12-15T08:55:18Z
dc.date.available 2024-12-15T08:55:18Z
dc.date.issued 2024
dc.identifier.other 572mas/571
dc.identifier.uri http://univ-bejaia.dz/dspace/123456789/25054
dc.description Option :Applied biochemistry en_US
dc.description.abstract Non-alcoholic fatty liver disease (NAFLD) is a common condition associated with obesity and metabolic syndrome, affecting approximately 25% of the global population. Our study explores the development of an effective treatment for non-alcoholic fatty liver disease (NAFLD), a condition for which there is currently no specific treatment. We studied the use of β2-agonists, such as formoterol, as a potential treatment for NAFLD, targeting lipid metabolism and inflammation. Rats fed a high-fat diet were divided into four groups: negative control, high-fat diet, treatment with formoterol, and treatment with salbutamol. Treatments were administered daily by injection for two weeks. Tissue and serum samples were analyzed to assess treatment effects. Treatment with formoterol and salbutamol significantly reduced adipose tissue weight and levels of liver enzymes (AST, ALT, GAMMA-GT), suggesting hepatic protection. β2- agonists show promising therapeutic potential for NAFLD, reducing hepatic fat accumulation and improving liver function. These findings offer prospects for future treatments targeting lipid metabolism and inflammation. Further research is needed to confirm these benefits en_US
dc.language.iso fr en_US
dc.publisher Université de béjaia en_US
dc.subject Formoterol en_US
dc.subject B2-agonistes en_US
dc.subject Salbutamol en_US
dc.title The action of B2agonists formoterol and salbutamol on non -alcoholic fatty liver disease induced by a high -fat diet (HFD)biochemical approaches . en_US


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